Configuring Web for ASP.NET 4.5 failed. You must manually configure this site for ASP.NET 4.5 in order for the site to run correctly. ASP.NET 4.0 has not been registered on the Web server. You need to manually configure your Web server for ASP.NET 4.0 in order for your site to run correctly.”
I manually created pool for with 4.5, in order to create it I had to do following:
Because there is no v4.5 shown in the gui, and typically you don't need to manually specify v4.5 since it's an in-place update. However, you can set it explicitly with appcmd like this:
appcmd set apppool /apppool.name: [App Pool Name] /managedRuntimeVersion:v4.5
Appcmd is located in %windir%\System32\inetsrv.
This helped me to fix an issue with Web Deploy, where it was throwing an ERROR_APPPOOL_VERSION_MISMATCH error after upgrading from v4.0 to v4.5
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